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计算机网络和信息集成教育部重点实验室学术报告(Christine Nardini博士,意大利 CNR IAC Mauro Picone 研究所)
发布日期:2017-5-10     发布者:刘肖凡     浏览次数:460

应赖大荣博士的邀请,意大利 CNR IAC Mauro Picone 研究所Christine Nardini博士将访问我院并作报告。详细信息如下。

 

演讲题目:Computational biology, mechanotransduction and autoimmune diseases

演讲者: Christine Nardini博士,意大利 CNR IAC Mauro Picone 研究所

 

演讲时间:518日(周四)上午10:00 -11:00

演讲地点:计算机楼二楼会议室(213

 

演讲摘要:With the technological revolution brought in by high-throughput biology, exact sciences have fiercely entered the realm of live sciences, with approaches supporting applications ranging from molecular biology to medicine, with the recent and particular focus on evidence-based medicine.

Over the time of this talk I will present the tools we developed with bases rooted in engineering and exact sciences (network construction, reconstruction and simulations) to approach a specific theme in medicine: degenerative diseases, a class of systemic, often autoimmune and chronic maladies, with no cure, consequent high societal costs and spreading at very fast pace worldwide.

In particular, with the design of a clinical pilot study in animals  (Nardini et al. 2016) and a pilot clinical study in humans (ClinicalTrials.gov ID: NCT01619176) we explored the systemic effects of mechanical stimulations delivered in the subcutaneous tissue, thanks to the collection of heterogeneous omic data (mRNA-, 16S-rRNA-, miRNA-seq), at different histological (blood, gut-intestinal microbiome, synovial tissue, subcutaneous tissue) and temporal point (before therapy, early genes activation, after therapy).

This lead to the realization that the molecular events triggered locally have a systemic resonance, a very well understandable fact in the frame of non-linear equation and chaos theory, whose translation in medicine is however far from trivial, leading to potential extremely innovative applications in medicine, here discussed with the model disease of rheumatoid arthritis.

 

演讲者简介:Dr.Christine Nardini ( CN ) is currently affiliated to the CNR IAC Mauro Picone in Rome where she is expanding her research interests deepening mathematical modelling. CN followed her Master degree in biomedical engineering at the university of Bologna in 1999 with a 2-year placement in a biomedical company (Medtronic), working in the area of anti-arrhythmic devices. After this experience in industry, she started a Ph.D. still at the University of Bologna in computational biology working at omic data mining, from 2002 to 2006. In this context, she has taught students enrolled on the International Master in Bioinformatics (University of Bologna, IT). A time as visiting scientist at Stanford and San Diego Universities (USA) she has set the bases for a durable collaboration (now at EPFL, Switzerland) and forged her interest in translational medicine. Later, from 2006 on CN worked at the Telethon Institute for Genetics and Medicine (TIGEM) in Naples (IT) on gene network reconstruction. She then exerted as full professor and PI at the CAS-MPG PICB in Shanghai, where she continue to mentor students, from 2008 to 2014, focusing to the development of methods for multiomic integration applied to autoimmune diseases, with a particular focus on the host-microbiome interaction and inflammation, with approaches ranging from the design and coordination of animal experiments, human pilot studies, and in silico modeling and simulations.  She has published academic papers  on well-known journals and conferences including Science, PNAS, Bioinformatics, Scientific Reports and so on, is reviewers for a number of funding bodies including Cancer Research UK; NSFC National Science Foundation of China; NIMAD National Institute for medical research Development of Iran, and serves as editors of several journals as BMC Bioinformatics, Bionanoscience and PLoS ONE and so on.